# Sex-Hormone Binding Globulin **Sex hormone-binding globulin (SHBG)** is a protein produced mainly in the liver that binds to sex hormones in the blood, controlling their activity. High SHBG levels mean more hormones are bound and less are available for use, potentially leading to symptoms of low testosterone in men and high testosterone in women. Low SHBG levels indicate fewer hormones are bound, allowing more to be active. SHBG plays a crucial role in regulating hormone levels, affecting health outcomes like muscle mass, bone density, and fertility. --- # Agent Instructions: Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter: ``` GET https://docs.beoptimal.ca/biomarker-panels/male-performance-panel/sex-hormone-binding-globulin.md?ask= ``` The question should be specific, self-contained, and written in natural language. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.