🥼Protocols in development

What are we currently working on?

Last updated: May 16, 2024

Conflicts to declare: None. Please remember to consult with a healthcare provider prior to undertaking any of the protocols available here.

  1. What studies support (or do not support) the specific steps included in the popular Huberman sleep protocol? protocol update

  2. How can we summarize the evidence in the scientific literature that favours earlier than standard efforts to lower ApoB for the purpose of reducing the long-term risk of ASCVD? What are the arguments against this position? What is the risk of iatrogenic harm if pharmaceutical medications are used to lower ApoB in younger individuals with otherwise "normal" ApoB levels? article

  3. How can we summarize the evidence in the scientific literature that favours earlier efforts to lower HbA1c and insulin levels for the purpose of longevity? article

  4. How good is the evidence for the purported health effects of cold plunges? protocol genesis

  5. Is there a role for empiric Zinc supplementation in a male with low-normal testosterone levels and some symptoms suggestive of lower-than optimal testosterone who has a dietary history potentially suggestive of inadequate dietary Zinc intake and an equivocal or low-normal plasma zinc serum concentration? (i.e. given the lack of sensitivity of plasma zinc testing to detect underlying zinc deficiency). protocol update

  6. How strong is the evidence for the Zone 2's unique benefits for mitochondrial health (or other longevity metrics, like cardiac stroke volume) relative to HIIT? protocol update

  7. Basic strength-training aside, what specific protocls can be used to develop functional strength that is positively correlatd to longevity (as measured by grip strength)? protocol genesis

  8. What reasonable and proportionate evidence-based practices can be recommended to avoid exposure to environmental toxins and endocrine disruptors like microplastics and phtalates, some of which have been causally linked to the development of atherosclerotic cardiovascular disease? protocol genesis

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